Adam and Eve Creation Essay Example for Free

Adam and Eve Creation Essay The Lord God formed man from the dust of the ground and breathed into his nostrils the breath of life, and man became a living being. (Genesis 2:7). The Hebrew for man is pronounced aw-dawm, from which Adam is derived. Its also related to aw-dawm-ah, which means red earth, or red clay indicating the natural earth elements that composed Adams body, and the body of every human being since. The Lord God took the man and put him in the Garden of Eden [see Where Was The Garden Of Eden?] to work it and take care of it. (Genesis 2:15). Adam wasnt going to lead an idle life he had a job right from his first day. For a little while, Adam was the only human being in existence (imagine being the only person on an entire planet!). The Lord God said, It is not good for the man to be all alone. (Genesis 2:18) So The Lord God caused the man to fall into a deep sleep; and while he was sleeping, He took one of the mans ribs and closed up the place with flesh. Then The Lord God made a woman from the rib. He had taken out of the man, and He brought her to the man. The man said, This is now bone of my bones and flesh of my flesh; she shall be called woman, for she was taken out of man. For this reason a man will leave his father and mother and be united to his wife, and they will become one flesh. (Genesis 2:21-24) Eves original name, when translated, meant simply woman, (a female man) just as Adam was known simply as man (a male man). He called her woman, and she called him man. Later, Adam named his wife Eve, because she would become the mother of all the living. (Genesis 3:20). Eve is derived from the Hebrew word which means life-giving. Eventually, besides Cain And Abel, they had Seth (Genesis 5:3), and numerous other children (Genesis 5:4). See more: Distinguish between problem-focused coping and emotion-focused coping Essay So God created man in His Own Image, in The Image of God He created him; male and female He created them. God blessed them and said to them, Be fruitful and increase in number; fill the earth and subdue it. Rule over the fish of the sea and the birds of the air and over every living creature that moves on the ground. Then God said, I give you every seed-bearing plant on the face of the whole earth and every tree that has fruit with seed in it. They will be yours for food. And to all the beasts of the earth and all the birds of the air and all the creatures that move on the ground everything that has the breath of life in it I give every green plant for food. And it was so. God saw all that he had made, and it was very good. And there was evening, and there was morning the sixth day. (Genesis 1:27-31). (see The Seven Days Of Creation) Adam and Eve had a perfect life in Eden. That is, until That Old Serpent slithered in. Fact Finder: What was Gods command to Adam (Eve had not yet been created) regarding a certain two trees in the Garden of Eden? Genesis 2:16-17

Classification According To Maturity Biology Essay

Classification According To Maturity Biology Essay INTRODUCTION The human eye is very nearly spherical, with a diameter of approximately 24 mm (nearly one inch). It consists of three concentric layers, each with its own characteristic appearance, structure and functions. From outermost to innermost, the three layers are the sclera, which protects the eyeball; the choroid, which nourishes the eyeball; and the retina, which detects light and initiates neural messages bound for the brain. The eye is partitioned into two chambers, a small anterior chamber and a larger vitreous chamber. Thus the basic layout consists of three concentric layers, two chambers, iris, pupil and the lens (Ross and wilson, 2001). Fig.1 Anatomy of the eye C:UsersDHINESHDesktopUntitled1.png The Lens One of very important optical element of the eye, the crystalline lens, lies right behind the iris. The lens takes its name from its resemblance to a lentil, or bean. In adults, the lens is shaped about 9 mm in diameter and 4 mm in thickness. The lens consists of three distinct parts: an elastic covering, or capsule; an epithelial layer just inside the capsule; and the lens itself. The thin, elastic capsule around the lens has two jobs. First, it moderates the flow of aqueous humor into the lens, helping the lens retain its transparency to light. Second, the elastic capsule moulds the shape of the lens varying its flatness and, thereby, the lens optical power. This variant in optical power is called accommodation. Lens grows throughout the life span; the outer, epithelial layer of lens continues to produce protein fibres that are added to the surface of the lens. Consequently, those protein fibres nearest the centre of the lens are the oldest (some were present at birth), whereas the fibres on the outside are the youngest. Between birth and 90 years of age, the lens quadruples in thickness and attains a weight of 250 mg. In the centre of the lens, the old fibres become more densely packed, producing sclerosis, or hardening, of the lens (Paterson, 1979). For good vision, the lens must be transparent and light must be able to pass through it easily, without loss or deviation. Like the cornea, this transparency depends on the material out of which the lens is made. Of all the bodys parts, the lens has the highest percentage of protein, and its protein fibres are lined up parallel to one another, maximizing the lens transparency to light. Anything that disturbs this alignment such as excess fluid inside the lens reduces its transparency. An opacity (or reduced transparency) of the lens is called a cataract. While some cataracts are minor, barely reducing the transmission of light, others undermine vision to the extent of blindness (Kyselova, 2004). Cataract Cataract is the opacification and crystalline formation of eye lens, associated with the breakdown of the eye lens micro-architecture, which interferes with the transmission of light onto the retina. Several biochemical processes for example, calcium deposition, oxidative stress, phase transition, altered epithelial metabolism, crystalline precipitation, calpain-induced proteolysis and cytoskeletal loss takes place during the development of cataract (Moghaddam, 2005). Fig.2 Normal, clear lens Fig.3 Lens clouded by cataract C:UsersDHINESHDesktopUntitled.png Fig.4 Etiology of cataract (Jacob, 1999) C:UsersDHINESHDesktopUntitled.png TYPES OF CATARACT A. Acquired cataract 1. Age related cataract a) Morphological classification i) Subcapsular cataract Anterior subcapsular cataract mainly associated with fibrous metaplasia of the epithelium present below the lens capsule. Posterior subcapsular cataract lies just in front of the posterior capsule and a clear vacuolated, granular or plaque-like appearance. Near vision is also most often impaired more than distant vision. ii) Nuclear cataract usually begins as an amplification of the changes most often seen with normal aging lens nucleus. It is often related with increased spherical aberration and also with an increased refractive index leading to myopia. Some elderly patients may consequently be capable to read yet again without spectacles. iii) Cortical cataract may be associated with the anterior, posterior or equatorial cortex. The opacities begin as clefts and vacuoles between lens fibres because of hydration of the cortex. Both cortical and subcapsular cataracts are white on oblique illumination and show black colouration, silhouetted against the red reflex, on retroillumination. b) Classification according to maturity i) An immature cataract means partially opaque lens. ii) A mature cataract means completely opaque lens. iii) A hypermature cataract means the leakage of water from the lens it leads to wrinkled and shrunken anterior capsule. iv) A morgagnian cataract means the total liquefication of lens cortex like hypermature cataract and it allows the lens nucleus to shrink inferiorly (Hejtmancik, 2004). 2. Presenile cataract Cataract may develop early in the following conditions, a) Diabetes mellitus Typically diabetic cataract is rare. In hyperglycemic conditions, the aqueous humor secretes high level of glucose and this excess of glucose diffuses into the lens. Aldosereductase metabolises glucose to sorbitol, which then accumulates in the lens, resulting in secondary osmotic over hydration of the lens substance. Nuclear opacities are common and tend to grow rapidly. Premature dystrophy may be seen due to decreased pliability of the lens. b) Myotonic dystrophy About 90% of patients, in third decade have fine cortical iridescent opacities, which evolve into visually disabling stellate posterior subcapsular cataract by the fifth decade. c) Atopic dertmatitis About 10% of patients with severe atopic dermatitis develop cataracts in the second to fourth decades. The opacities are often bilateral and may mature quickly. Shield like anterior subcapsular plaque which wrinkles the anterior capsule is characteristic. Posterior subcapsular opacities resembling a complicated cataract may also occur. 3. Traumatic cataract Trauma is the major risk factor for unilateral cataract in individuals. The following risk factors are involved in traumatic cataract, a) Direct penetrating injury to the lens. b) Concussion may cause an imprinting of iris colour on the anterior lens capsule (Vossius ring) as flower shaped cortical opacities (rosette cataract). c) Electric shock and lightening are rare causes. d) Ionizing radiation. e) Infrared radiation- In glassblowers, the IR rays causes exfoliation of the lens capsule which results in thickening of the superficial portion of the capsule and it further splits the deeper layer and protrudes into the anterior chamber. B. Drug induced cataract a) Steroidal drugs may induce cataract. Initially the lens opacities formed in posterior subcapsular region spreads into the anterior region. The relation between dose, duration of administration and the cataract development is unclear. It is understood that children may be more at risk to the cataractogenic effects of systemic steroids and genetic susceptibility may also be of significance. Patients who develop lens physiological changes should have their dose decreased to a minimum, reliable with control of the underlying disease, and if feasible be considered for alternate drug therapy. Premature opacities may regress if therapy is discontinued, alternatively progression may occur despite withdrawn and warrant surgical intervention. b) Chlorpromazine may cause the deposit of innocuous fine, stellate, yellowish brown granules on the anterior lens capsule within the papillary area. The deposition of granular material may accumulate on the corneal endothelium and deep stroma. Both lenticular and corneal deposits are dose -related and irreversible. In very high doses (>2400 mg daily), this drug may cause retinotoxicity. c) Lens opacities may occur due to the irregular use of Busulphan (Myleran) for the treatment of chronic myeloid leukaemia. d) Amiodarone, used in the treatment of cardiac arrhythmias, causes visually inconsequential anterior subcapsular lens deposits in about 50% of patients on moderate to high doses. e) Gold used in the treatment of rheumatoid arthritis, causes harmless anterior capsular deposits in about 50% of patients on treatment for more than 3 years. f) Allopurinol, used in the treatment of hyperuricaemia and chronic gout, increases the risk of cataract formation in elderly patients, if the cumulative does exceeds 400 g or duration of administration exceeds 3 years. C. Secondary cataract A secondary (complicated) cataract grows as a result of some other primary ocular diseases. i. Chronic anterior uveitis is the main cause of secondary cataract. The earliest finding is a polychromatic lustre at the posterior pole of the lens which may not progress if the uveitis is arrested. If the inflammation persists, posterior and anterior opacities developed may progress to maturity. ii. Acute congestive angle closure glaucoma may cause small grey white anterior, subcapsular or capsular opacities within the papillary area. a. Myopia (Pathological) is linked with posterior subcapsular lens opacities and early-onset nuclear sclerosis, which may ironically increase the myopic refractive error. Simple myopia, however, is not associated with such cataract formation. b. Hereditary dystrophies such as retinitis pigmentosa, gyrate atrophy, leper congenital amaurosis and stickler syndrome may be associated with posterior subcapsular lens opacities. Cataract surgery may occasionally improve visual acuity even in the presence of severe retinal changes (Kanski et al., 2003). Free radicals involved in cataractogenesis Free radicals may be formed either by the reduction of molecules by electron transfer or by the haemolytic cleavage of covalent bond. Both these reactions may be enzymatic or non-enzymatic. Due to the presence of an odd unpaired electron in its outermost orbital, these free radicals are unstable and readily react with neighbourhood molecules and extract electrons from them, converting the attacked molecule into a few radical, which in turn attacks another molecule generating more free radicals and so on. This enables free radicals to induce chain reactions that may be thousands of events long. A free radical reaction is terminated by reaction between two free radicals or neutralization by antioxidants (Uday et al., 1999). Fig.5 Pathways of ROS formation C:UsersDHINESHDesktopUntitled 3.png Generation of free radicals Biological free radicals include reactive oxygen species, reactive nitrogen species, reactive sulphur species, free radicals obtained form xenobiotics. a) Superoxide anion radical (O2.-) It is generated from NADPH oxidase and from mitochondria. i) NADPH oxidase is present in the lysosomal cell membranes. It steals electron from O2 resulting in the formation superoxide anion radical (O ·2-). It is converted to hydrogen peroxide and is a spontaneous reaction which is known as respiratory burst. This hydrogen peroxide may react with the chlorine in the presence of myeloperoxidase to form hypochlorous acid or it may produce hydroxyl radicals, by the Fenton reaction which uses the metal ion Fe3+. ii) From Mitochondria: Ubiquionone, which is a terminal acceptor of electron, is converted to semiquinone (free radical). By reacting with O2, it forms (O ·2-) super oxide radical with H2O2, it produce hydroxyl radical ion. b) Hydrogen Peroxide H2O2 SOD It is formed by the dismutation of superoxide by the enzyme superoxide dismutase. O · 2 + O ·2 Hydrogen peroxide is generated from i) Aminoacid oxidases: Flavin is a co-enzyme required for the oxidative deamination of amino acid. The reduced flavin attacks molecular oxygen to form hydrogen peroxide. ii) Xanthine oxidase: Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and hydrogen peroxide is released from molecular oxygen. iii) Peroxisomes: Peroxisomes is the site of  Ã‚ ¢-oxidation of fatty acids.  Ã‚ ¢- Oxidation of the fatty acids is catalysed by acetyl co-enzyme-A dehydrogenase. During this process, a co-enzyme called FAD which donates two electrons gets reduced to FADH2. Again it is converted to FAD. During that process it gives out O2 and H2O (Kovaceva et al., 2007). c) Hydroperoxyl radical They are highly lipophillic and capable of initiating lipid peroxidation. Lipid peroxidation Lipid peroxidation is a self- perpetuating common process and involves the conversion of lipid components from cell organelles into lipid peroxides resulting in the formation of a pigment known as lipofuscin. Lysosomic reactive oxygen species are formed as a result of complex oxidative chain reactions in mitochondria during energy production. H2O2 formed in smaller amounts by mitochondria pass through walls of lysosome and react with Fe (II) in a reaction known as Fenton reaction to form potent hydroxyl radicals which cause lipid peroxidation (Halliwell, 2001). Malondialdehyde is the major reactive aldehyde resulting from the peroxidation of biological membrane polyunsaturated fatty acids (PUFA). MDA, a secondary product of LPO, is used as an indicator of tissue damage by a series of chain reactions. MDA is a by-product of prostaglandin biosynthesis. It reacts with thiobarbituric acid and produces a red-coloured product. MDA is a mutagenic and genotoxic agent that may contribute to d evelopment of human cancer. Ca2+ ATPase The Ca2+ ATPase is a transport protein in the cells that serves to eliminate calcium (Ca2+) from the cell. It is essential for maintaining the amount of Ca2+ within the cells. Based upon the electrochemical gradient calcium ion enter into the cells through the trans membrane. This process is important for the cell signalling by which it lowers calcium level. Thus it is necessary for the cell to utilize ion pumps to remove the Ca2+. The Ca2+ ATPase is expressed in a variety of tissues, together with the brain (Hightower et al., 1982). IN VIVO MODELS IN CATARACT (Gupta, 2004) 1. Sugar cataract i) Galactose induced cataract The changes associated with galactose cataractogenesis include the initial reduction of galactose into dulcitol through intervention of aldose reductase with NADPH as a co-factor. Accumulation of dulcitol in the lens, (since it is not metabolized) creates cellular hypertonicity associated with and/or followed by a cascade of events, which includes an influx of water, swelling of the lens fibres, epithelial cell edema, damage of plasma membrane, compromise of cellular permeability, a drop in myinositol level, a reduction in Na+ K+ ATPase activity an influx of Na+ and Cl- and an efflux of K+ and the loss of glutathione and aminoacids. These are the morphological, biochemical, enzymatic and molecular alterations in the lens associated with galactose cataracts. ii) Alloxan induced cataract Alloxan is a cyclic urea analog which is highly reactive molecule that is readily reduced to dialuric acid, which is then auto oxidized back to alloxan resulting in the formation of hydroxyl radical, O2.-, including H2O2 (hydrogen peroxide). However, the other mechanism reveals the ability of alloxan to react with protein sulfhydryl groups on hexokinase, a signal recognition enzyme in the pancreatic ÃŽ ²-cells that couples changes in the blood glucose concentration to the rate of insulin secretion. By this mechanism, inhibition of glucokinase and other SH containing membrane proteins on the ÃŽ ²-cells would eventually result in cell necrosis within minutes. iii) Streptozocin induced cataract Diabetes related cataractogenic changes are seen in the animals injected with streptozocin. This streptozocin initiates cytotoxic action in pancreatic ÃŽ ² cells because sreptozocin contain glucose molecule and highly reactive nitrosourea side chain. It binds to the membrane receptor to generate structural damage. At the intracellular level three major phenomena are responsible for ÃŽ ² cell death, i) Methylation ii) Free radical production iii) Formation of Nitric oxide (NO). The damage caused to ÃŽ ² cells alters the sugar metabolism leading to diabetes. 2. Selenite induced cataract Selenite cataract resembles human cataract in many ways such as insoluble protein, vesicle formation, increased calcium, reduced glutathione (GSH) and decreased water-soluble proteins. However, selenite cataract shows no high molecular weight protein aggregation or increased disulfide formation and is dominated by rapid calpain-induced proteolytic precipitation, while senile cataracts may be produced by prolonged oxidative stress. 3. Naphthalene induced cataract Naphthalene is oxidized in the liver initially to an epoxide and then it converted into naphthalene dihydrodiol. This stable component is converted enzymatically into dihydroxynaphthalene to reaching the eye. Being unstable at physiological pH, 1, 2- dihydroxynaphthalene and spontaneously autooxidises to 1, 2- naphthoquinone and H2O2 . It alkylates proteins, glutathione and aminoacids and generates free radicals. 4. Glucocorticoid induced cataract Glucocorticoid cataract results in the formation of steroid- adduct protein, induction of transglutaminase and reduction of ATPase activity may lead to cataract. Steroid cataracts are produced by the activities of glucocorthicoids and progressed by way of production of oxidative stress similar to other types of cataract. 5. L- Buthionine S, R- Sulfoximine (BSO) induced cataract Glutathione is present in mammalian lens in high concentrations and is involved in the protection of lens against oxidation. In most of the cataracts the decrease in its level is observed. 6. Smoke induced cataract Cigarette smoke contains trace and heavy metals. The increased metal contents in lens cause lens damage by the mechanism of oxidative stress-forming oxygen radicals, via metal catalyzed Fenton Reaction. In other words cigarette smoke is associated with the accumulation of iron and calcium. 7. UV radiation induced cataract Epidemiological studies have exposed a link between exposure to UV radiation in sunlight and development of cataract. Experimental studies confirm that ultraviolet (UV) radiation induces cataract. There is, however, a lack of data on the age dependence in experimental UV radiation-induced cataract. 8. Microwave induced cataract Microwave radiation has been reported to produce posterior subcapsular and cortical cataracts in rabbits and dogs within a short span of time. 9. Transforming Growth Factor ÃŽ ² (TNFB) induced cataract TGFB is induced by injecting approximately 60 ng TGFB into the vitreous. TGFB induce lens epithelial cells to undergo molecular modify and abnormal morphologic that mimic the changes observed in human posterior subcapsular and cortical cataract (Gupta, 2004). IN VITRO MODELS IN CATARACT (Gupta, 2004) Induction of cataract in isolated animal lenses maintained in organ culture has become a convenient, quick and appropriate method for testing the anticataract efficacy of an agent. Opacification of lens is induced by generating oxidative stress/ hyperglycemic/ hypergalactosemic conditions around the lens by supplementing the culture medium with a variety of exogenous substances. 1. Oxidative stress induced cataract Oxidative mechanisms play an important role in many biological phenomena including cataract formation. Formation of the superoxide radical in the aqueous humor, lens and its derivatization to other potent oxidants may be responsible for initiating various toxic biochemical reactions leading to the progress of cataract. In vitro such cataracts are induced by agents like selenium, H2O2, photosensitizers and enzyme xanthine oxidase. 2. Selenite induced cataract In vitro cataract is produced by supplementing the tissue culture medium with 25 to 100 mM sodium selenite in which freshly enucleated transparent rat lenses are incubated at 370C. This causes membrane damage and faint cortical opacities within 24 h. 3. Photochemically induced cataract Riboflavin, a photosensitizer, is supplemented in the culture medium to induce cataract in cultured lenses. Micro quantities (4-200  Ã‚ ­M) of riboflavin lead to severe physiological damage and opacification within 24 h after exposure to light. The initial membrane damage is evidenced by a disturbed cation ratio between lens water and the medium of incubation. Riboflavin on getting photosensitized generates free radicals in a sequence of reactions. Lenses are maintained in organ culture for 24 to 72 h. The lenses are divided into four groups and incubated in the dark and light both in presence and absence of riboflavin. The lenses are exposed to light with two 15-w daylight fluorescent lamp placed at 8 inches above the cluster plate. The culture medium is replaced every 24 h. Riboflavin shows no effect on the lens in the absence of light, and light without riboflavin has no significant effect. opacification starts in the equatorial zone and gradually extends towards the centre of the lens. 4. Enzymatically induced cataract Supplementation of culture medium with 1 mM xanthine and 0.1 unit xanthine oxidase, which act as substrate and enzyme respectively, leads to generation of superoxide radical. The lenses suffer severe oxidative damage and turn opaque within 24 h when incubated in culture medium at 370C. 5. Hydrogen peroxide induced cataract Incubation of lenses in medium containing 50-500  Ã‚ ­M H2O2 and it produce cataract. Opacification starts in the equatorial region within 24 h. The entire superficial cortex becomes opaque by 96 h. Due to the high instability of H2O2, the medium is changed every 2 h during the first eight hours. 6. Sugar induced cataract Transparent and undamaged lenses are incubated in a basis culture medium with fetal calf serum for 24 to 48 h. In the control group the medium is supplemented with glucose (30 mM), lenses develop opacity in the subcapsular region on day 1 and in the central region on day 2. Biochemical analyses reveal raised polyol, malondialdehyde levels and water content, and decreased glutathione levels in these lenses. 7. Steroid induced cataract Steroid-induced experimental cataract is produced in vitro by incubating the transparent lenses in the medium containing methyl prednisolone (1.5 mg/ml). The test agent and methyl prednisolone added alone and together to the medium form drug control, control and treated groups respectively. Early cataract around the equator is produced within 24 h of incubation. Incubation period may be extended to 48 h for dense opacity. Morphological changes and modulation in biochemical parameters between the groups may show the potential of the anticataract agent. 8. Naphthalene induced cataract TC-199 medium is used for the preincubation of lens. Stock solution of napthalene dihydrodiol is prepared in 20% ethanol at 2.5-10-3 M concentration. The stock solution is diluted 1:100 to obtain the final concentration of 25.5 -10-5 M. The final osmolarity of the solution is 295-300 m Osmol. Rat lenses are incubated in TC-199 medium containing napthalene metabolite solution. Medium is renewed daily till 72 h. Lenses remain clear during the initial 24 h but from shell-like opacity around the nucleus by 48 h. Opacification becomes more peripheral and widespread after 72 h. At 48 h, under such conditions of incubation, development of opacity mimics the in vivo napthalene cataract. Naphthalene is oxidized in the liver first to an epoxide and then is altered into naphthalene dihydrodiol. This stable component on reaching the eye gets converted enzymatically to dihydroxynaphthalene. Being unstable at physiological pH, 1,2 dihydroxynapthalene sponaneously auto oxidises to 1,2 naphthoquinon e and H2O2. It alkylates proteins glutathione and amino acids and generates free radicals. There is a loss of protein thiol in this reaction and the products are less easily digestible by pancreatin than normal lens protein (Rees and Pirie, 1967). 9. Ca2+ induced cataract In this model, the control group contains the lenses incubated in the medium enriched with 20 mM Ca2+ or 1x 10-2 mM A23187 calcium ionopore. The treatment group lenses are cultured in the calcium and the test drug-containing medium. Incubation period can range from 24-72 h (Gupta, 2004). Fig.6 Mechanism of action of glucose-induced cataract C:UsersDHINESHDesktopUntitled 7.png Under physiological conditions, glucose is metabolized through the glycolytic pathway. An excess amount of glucose is converted to sorbitol by enzyme aldose reductase via polyol pathway. The glucose conversion into sorbitol by utilizing NADPH results in the reduction of NADPH/NADP+. Moreover, sorbitol undergoes oxidation to fructose by using sorbitol dehydrogenase (SD). Sorbitol does not easily cross cell membrane. Intra lenticular accumulation of sorbitol, leads to lens damage (Kyselova, 2004). Fig.7 Biomorphological changes during cataract formation C:UsersDHINESHDesktopUntitled 66.png As, the lens starts to swell in response to the hyper osmotic effects of polyol accumulation, membrane permeability changes resulting in an increase in lenticular sodium and decrease in the levels of lenticular potassium, reduced glutathione, ATP and free amino acids. The overall antioxidant status of the lens decreases because of depletion of GSH (Kyselova, 2004). Mechanism of action of calcium-induced cataract Fig.8 Calcium transport pathway Increased levels of lenticular calcium activate calcium dependent proteases. The activated proteases hydrolyze cytoskeletal proteins and lens crystalline. Crystalline cleavage would result from lower molecular weight peptides that could, in turn, aggregate to form higher molecular weight proteins (Wang et al., 1996). Various methods for the prevention of cataract The development of newer drugs for treatment of cataract mainly aims, interacting at the level of changed lens metabolism and lens pathophysiology. The in vitro, in vivo studies are used to identify the anti cataract agents. This epidemiological studies may be widely classified in the following categories (Gupta et al., 1997). Aldose reductase inhibitors Agents acting on glutathione Nonsteroidal anti -inflammatory drugs Vitamins, minerals and antioxidants Miscellaneous agents. 1) Aldose Reductase Inhibitors These drugs are aimed to prevent the metabolic dysfunctions of diabeties by polyol pathways. Aldose reductase inhibitors prevents the accumulation of sorbital within the lens would have an osmotic effect bringing in water and causing swelling and opacification. Sorbinil a spirohydantoin became the most powerful sorbitol lowering agent. Sorbinil prevents increased fluorescence and protein aggregation and it also acts as an antioxidant. 2) Non Steroidal Anti inflammatory Drugs The NSAIDS broadly studied are paracetamol, aspirin, Ibuprofen, sulindac, naproxen, and bendazec. The NSAIDS provide adequate productive effect to lens protein through various steps like acylation, carbamylation and inhibition of glycocylation. Some of them are also reported to inhibit lens AR to varying extent. NSAIDS contains antioxidant properties also. Most of the studies on the evaluation of anticataract potential of drugs have been conducted by feeding the drugs by oral route. 3) Agents which act on glutathione Glutathione is a tripeptide thiol known to control calcium inflex and protect lens protein from various agents like glucose and galactose. With advancing of age there is a considerable decrease in the concentration of glutathione and the decrease more prominent in lens with cataract. 4) Vitamins, minerals and antioxidants If oxidation in lens leads to cataract formation, then is feasible to prevent it by the use of antioxidants such as vitamins C and E and perhaps ÃŽ ²-carotene. The potential role of vitamins and antioxidants in preventing various diseases is well documented there are reports suggesting beneficial effect of vitamins like C and E in preventing cataract. Beta -carotene has also been demonstrated to protect lens damage by hematoporphysin. Ascorbate protects rubidium uptake against free radical damage and prevents light induced protein cross linking. Protective effect of vitamin C has been also reported in various in vitro studies. Vitamin E has been found to delay cataractogenesis in diabetic rats and in Emory mouse. Vitamins C and E,  Ã‚ ¢- Carotene and other anticataract agents probably act via a common mechanism of their scavenging properties of free radicals (Gupta et al., 1997b). Antioxidant enzymes 1) Superoxide Dismutase (SOD) SODs are a family of metalloenzymes that transfer superoxide in to hydrogen peroxide (H2O2) and represents the first line of defence against oxygen toxicity. 2O2- + 2H → H2O2 + O2 Three isoforms of SOD have been found. The first is mainly found in the cytoplasm of cells and it containing Cu and Zn at its active site (Cu/Zn SOD-1), the second containing Mn at its active site is located in mitochondria (Mn SOD-2) and the third (Cu/Zn SOD-3) is present in the extracellular fluid like plasma. SOD is a stress protein which is synthesized mostly in response to oxidative stress. It is found that little amount of Cu, Zn and Mn metals are crucial for maintaining the antioxidant activity of SOD (Halliwell, 1994; Ray and Husain, 2002). 2) Glutathione Peroxidase (GPx) GPx is one of the most important enzymes responsible for the degradation of organic peroxides and hydrogen peroxide in the brain. GPx catalyse the oxidation of GSH to GSSG at the expense of H2O2. There are two isoforms have been identified, selenium-dependent which is highly active towards H2O2 and organic hydroperoxides and selenium independent GPx. GPx activity has been reduced in selenium deficiency (Muller et al., 1984; Son et al., 2007). 3) Catalase (CAT) It is a heme-containing protein present in most cells. 2H2O2+ 2H2O → O2 Catalase is 104 times faster than GPx. It is having four protein subunits, each containing a heme Fe (III)-protoporphyrin group bound to its active site. GPx and CAT were found to be important in the inactivation of many environmental mutagens (Ray and Husain, 2002). 4) Glutathione (GSH) GSH has major intracellular antioxidant molecule and it is a tripeptide synthesised by enzymatic reaction involving two molecules of ATP from aminoacids like glutamate, glycine and cysteine. It plays a very crucial role in detoxification of peroxides and electrophilic toxins, mainly by acting as a substrate for GSH transferase and GSH peroxidase. It was shown that weakening of GSH enhances cerebral ischemic injury in rats (Mizui et al., 1992; Son et al., 2007).

N1 Solutions LLC Business Technology Analysis

N1 Solutions LLC Business Technology Analysis Student: Suresh Barre COMPANY PROFILE N1 Solutions LLC. Provides in-depth experience and expertise in legacy application development, release management, and maintenance. We understand that Applications are the key point of any organization. N1 Solutions LLC. Offers VALUE ADD services for both internal and external facing client applications. Their resources come equipped with proven project management techniques, application development methodologies, and release / change management principles whether it is a single resource requirement or staffing up a complete project team, team N1 Solutions LLC has it all. N1 Solutions LLC capabilities help companies improve revenue, drive efficiencies and productivity improvements, automate key processes, reduce process/cycle times, and transform business data into valuable information. N1 Solutions LLC service spectrum consists of a range of technology offerings like: 1. Application Maintenance and Enhancement 2. Custom Application Development 3. Data Centric Services 4. Implementation Methodologies Total no. of Employees: 120 Financial synopsis N1 Solutions LLC is well-established in growth markets and aims to be the right partner for its customers. The company combines deep local knowledge with global capability. The company is trusted across its network for its standard of governance and its commitment to making a difference in the communities in which it operates. N1 Solutions LLC annual revenues more than 20M broke down roughly 20% license, 35% pro services, and 45% maintenance. For new sales, maintenance was 18-20% of license revenue and implementation services roughly equaled license revenue. Here are the few nuggets and features I found so far from this kind of work environment. Transparent Open Communication Give and Take policy Work-Life Balance Training Development-Focused Recognition for Hard Work Strong Team Spirit Clients: 3i InfoTech Walmart Cognizant Technology Solutions Intelligroup IGATE Robert Half Technology HCL Infosys OPPURTUNITIES The experience with N1 Solutions will provide me the opportunity to achieve the real world experience in the ground of Information Technology, Sales Force cloud computing technology and implementation. From the beginning I have been afford the opportunity to partake as an equal member of their internal process. Internship Technology: Salesforce Salesforce Inc. is a global cloud computing company headquartered in San Francisco, California. Though best known for its customer relationship management (CRM) product. Internship objectives: Working as a salesforce intern, performing duties and activities and analyzing them in different perspectives. Here I am presenting few important internship objectives. To get familiarity with Apex code, Triggers and Visualforce. To Learn SOQL (salesforce object query language) and SOSL (salesforce object search language). To get experience with building salesforce apps and objects. To learn integration techniques using web services and APIs. To get experience in Salesforce customization. To learn Creating Apex business logics. To get salesforce 401 Developer Certification. Personnel Development Goals Observing and learning different projects. To improve business communication skills Planning and organizing client interaction. To develop reporting skills To get experience with managerial skills 3.0 LEARNING OBJECTIVES During the course of my internship, I had a great and vivid exposure in Salesforce technology and implementation. I also had an opportunity to get familiarize with many programs and tools. Also had an opportunity to interrelate many real time Salesforce implementations and design. Programs and tools used and learned during the internship Salesforce Edition: Enterprise Features: Workflow approval automation Report history tracking Profiles and page layouts Custom app development Integration via web service API Salesforce Identity Salesforce Private AppExchange Project Management Tool: Smart sheet for sales force Features: Import from Microsoft Project or Excel Multiple levels of tasks Single sign-on from Salesforce Share project sheets and attached files with anyone inside or outside your Salesforce account IDE (Integrated Development Environment): Eclipse Helios Features: Market place client Open Implementation Package Name abbreviations Virtual Folders Compare Configurations Instance counts Support for Apache Tomcat 7 Other Tools: HTML, Java, .net, Visualforce, Saas and apex code. PROJECT I got an opportunity to involve in a real time project for an implementation of Salesforce architecture. Here is the snapshot of the project I was involved. By using cloud computing technologies the new way of building and running applications are being enabled where applications are accessible as utilities over Internet rather than different softwares running on server or desktop. This is a fairly common model for consumer applications like email etc., and also some business applications, such as customer relationship management. The website force.com platform as a service is the first of its kind in the world, which enables developers to create as well as deliver any type of business applications in the cloud, without software which is entirely on-demand. This technology is a breakthrough new concept. It makes businesses widely successful by making them translate their ideas into usable applications in a very short time. Developing and running these kind of business appliactions with regular software is a complex, not so fast and costly. To overcome these issues a new model, called cloud computing has been brought into existence. To stop buy and maintain hardware and software applications in the cloud are delivered as services. Salesforce.com, over the last decade helped and established this model with applications bussiness. More recently, force.com opened up and made it as open source so anyone can build and run bussiness applications on its server. Salesforce.com mastered this model with applications for business since ten years. Recently Force.com made available its proprietary technologies as open source for anyone who is building and developing bussiness applications and then running them on force platform. This platform allows you to store structured data, implement and run business logic with rules of workflow techniques, custom code and also custom codes and approval process, web browser support, integration with other applications as well. The overall scope of this project is all, but limited to To develop an application for sales forecast details. Provide the Sales forecast details of a company product. Ease of access and use. Secured analysis (confidentiality). Views about present status. PROPOSED SYSTEM In the previous CRM system, there are lot of problems, so a new technology is being used in this project called as cloud computing. To develop an application in the cloud computing environment and to deploy it and also launching it in the cloud is being proposed in this project. It is called as salesforce environment. A simple application developed and deployed in the cloud by using the tools and in the environment there itself. System Specifications User Requirements: A high-speed Internet Connection is needed as an interface between the service provider and User. User name and Password provided by the administrator is needed to the user to work with the application. Hardware Requirements: Processor: 32 bit Processor Ram: 512 Mb Hard Disk: 40 GB Internet: 512 Kbps high speed internet connection Software Requirements: OS: All OS supporting internet browsing. Environment: Force.com Environment Language: Visual Force Functional Requirements Understand the cloud environment provided by SalesForce.com Learning VISUALFORCE Developing an application using Visualforce in the SalesForce.Com Environment Deploying the application Providing the User accounts Accessing the application from user accounts and should work with the applications clearly. Other Non-functional Requirements: Performance Requirements: The performance will be fully based on the Internet connection. The user may not worry about their local system. The local system will be only used as a terminal. Safety Requirements: There are the possibilities of data loss due to the interruption of connection in Internet. So the user must ensure about his uninterrupted internet connection. Security Requirements: All the security issues will be provided by the service provider itself (SALESFORCE.COM). No users are allowed to enter and view the details without proper authentication (password protection). ROLES AND RESPONSIBILITIES       This role is more about learning people than coding new fields in Salesforce. One should have familiar with sales process and sales team in a company. Applying and acquiring Salesforce admin and developer skillset as required for project and assignments. Creating Salesforce customization like creating layouts and pages, learning user maintenance, database de-dumping and cleanup, creating reports and dashboards through Salesforce platform. To learn managed outsourced Salesforce implementation and development process. Apply and acquire technical analysis as required per each task, data extraction from old to new system. Salesforce Cloud Application Layout: Dashboard Reports Accounts creation Forecast 6.0 Learning experience Internship is a way to show you if that is the career is you really want. And have first hand experience on what youre going to do, if you choose the trade. This is an option to pay your dues early on. By gaining early experiences as an intern, earn myself a bit more of a leg-up to start. Internship given me exposure to new and professional situationsà ¢Ã¢â€š ¬Ã‚ ¦with a safety net. They had given me real opportunities for practical application of skill, but are also there to catch me if there is a problem along the way. They provide you experience with a chance to grow. You just dont stop after some years in the trade. The open-minded mentality, Ive experienced, can differentiate successful, progressive professionals from the rest. My learning focus and implementing contribution for the project: Creating Workflow Rules: To automate organizations standard processes by configuring workflow rules. Every single workflow rule consists of: A criteria which determines when the software salesforce executes the workflow rule. And also any changes that causes any record to match this can trigger the workflow rule-it even changes it to hidden fields. The actions immediately to take, when this workflow rule executes. For an example, the software Salesforce sends automatically an email that notifies the opportunity team when a new high-value opportunity is created. There are Time-dependent actions which the Salesforce software queues when the workflow rule executes. Creating Page layouts and Field level security: Field-Level Security It restricts users to edit files and also view them by any means, which includes reports and search results, list views and related lists and email and also mail merge templates, with custom links, connect offline to the API and when also synchronizing data or importing personal data. It overrides any weak restrictive field access settings in the pages layouts and also mini page layout. For an example, if the field is required and read only in the page layout in the field level security settings, it overrides the page layout and the field will be read only for the user. It overrides low restrictive field settings in layouts of search. For example, if a field is visible in the search layout but hidden for certain users via the field-level security settings, the field-level security overrides the search layout and the field will be hidden for those users. For an example, if it is any field, which is visble Page Layouts It controls the layout, organization of detail and edit pages , related lists, which fields, custom link users see on detail and edit pages only. And also control standard and custom buttons display on detail pages as well as related lists. Page layout will determine whether fields are visible, read only, or required, on detail and edit pages only. In Personal category , by going into Contact Manager, and to Group, and Professional Editions, and to control which fields users can access in related lists, and to list views, reports, and to Connect Offline, and to email and mail merge templates, and to custom links, and when synchronizing data or importing personal data. In Professional category, by going into Enterprise, and to Unlimited, Performance, and Developer Editions, and to determine some aspects of mini page layouts, including record type and profile associations, related lists, fields, and field access settings. The visible fields and related lists of the mini page layout can be further customized, but the other items inherited from the associated page layout cannot be changed on the mini page layout itself. Mini page layouts display selected fields and related lists of records in the mini view of the console. It Should not be used to secure data, if we take an example, by removing the Edit button from a page layout, it doesnt prevent users from using inline editing to modify the already established or any records. And to prevent the users from editing data, it uses any number of combination of sharing rules, field-level security, page layout field properties, validation rules, object permissions, and Visualforce pages. Sandbox Testing: Sandboxes create copies of your organization in separate environments. Use them for development, testing, and training, without compromising the data and applications in your Salesforce production organization. Sandbox Types: Developer Sandbox These sandboxes are meant for using coding and testing to be in an isolated environment. These include production organizations configuration which is also known as metadata. Developer Pro Sandbox These are the sandboxes that are intended for developing and testing in the isolated environment. These include the metadata of the organization. These have more storage than developers sandboxes. This allows for more robust test data sets and enables the environment to handle development testing more. Partial Copy Sandbox These are intended for using as testing environments. These can be used for testing tasks like user acceptance testing, training and integration testing. These include metadata configuration, your production data as defined by this sandbox templates. Full Sandbox These sandboxes are intended to be used as testing environment. Only sandboxes support performance testing and load testing and staging. These are a replica of your production organization. This includes all data including metadata. Refresh interval length makes it difficult to use full sandboxes for development. When you create a Full sandbox, you also have to decide how much field tracking history and Chatter activity to include. The default is to omit field tracking, but you can include up to 180 days of field tracking. Specify fewer days to avoid generating an excessive amount of data if you track field history for many objects in your production organization. Chatter activity data can be extensive, which can add a significant amount of time to your Full sandbox copy. Validation Rules Validation rules verify that the data a user enters in a record meets the standards you specify before the user can save the record. A validation rule can contain a formula or expression that evaluates the data in one or more fields and returns a value of True or False. Validation rules also include an error message to display to the user when the rule returns a value of True due to an invalid value. Salesforce runs validation rules before creating records submitted via Web-to-Lead and Web-to-Case, and only creates records that have valid values. Validation rules continue to run on individual records if the owner is changed. If the Mass Transfer tool is used to change the ownership of multiple records, however, validation rules wont run on those records. Workflow Rules and Approvals: Each workflow rule consists of: The criteria that determines salesforce executes the workflow rule. And any change that causes the record to match the criteria triggers the workflow rule- it even changes to hidden fields. Workflow automates some types of actions which are as: Email Alerts-Send an email to one or more recipients. It can automatically send the sales management an email alert where the sales representative qualifies a large deal. Tasks-Assign a new task to a user, role, or record owner. It can automatically assign follow-up tasks to a support representative one week after a case is updated. Field Updates-This Updates the value of a field on a record. This will automatically change the Owner field on a contract 3 days before it expires. Flow Triggers-It Triggers an auto launched flow. It triggers the wrokflow actions, which are formerly available in a pilot programme, are superseded by using the process builder. Outbound Messages- this sends a secure configurable API message to a designated listener. For an example, this will automatically initiate a reimbursement process for the approved expense report after triggering an outbound API message to the external HR system. Approvals This is an automated process where the organization can use to approve salesforce records. This process explains in detail the steps necessary for the record, for the approval and also decides who has to approve it at each step. These steps can apply to each record in the process or certain defined by the administrator. It also specifies for any action taken in the records for approval. Apex code: Apex is an object-oriented programming language which allows developers to execute flow and transaction control statements on the Force.com server. It uses syntax that almost looks like java and this also acts like database stored procedures. Apex also enables developers for adding business logics and visualforce pages. This code can be started by web service requests and also from triggers on objects. Apex is: Integrated, Easy to use, Data focused, Rigorous, Hosted, Multitenant aware, automatically upgradeable, easy to test, Versioned. Visualforce Visualforce is a framework which allows developers to build fully sophisticated, custom UIs that can be hosted nativly on the Force.com platform. The Visualforce framework includes a tag-based markup language, similar to HTML, and a set of server-side standard controllers that make basic database operations, such as queries and saves, very simple to perform. In the Visualforce markup language, every Visualforce tag relates to a coarse or fine-grained UI component, such as a section of a page, a related list, or a field. The behavior of Visualforce components can either be controlled by the same logic that is used in standard Salesforce pages, or developers can relate their own logic with a controller class written in Apex. Visualforce page definition consists of two primary elements: Visualforce markup HTML, JavaScript, or any other Web-enabled code are tagged by visual embedded within a single tag. It defines user interface markup of components are to be included on the page, and they should appear the way they should. A Visualforce controller It is a set of procedural instructions that specifically tells what happens when the user starts to interact with the specified components in associated Visualforce markup, such as when a button or a link is clicked. They also provide access to data which should be displayed and can modify component behavior. A developer can use standard controller provided by the Force.com platform, or add some custom controller logic by using a class which is written in Apex: A standard controller which consists of the same functionality and logic used for a usually standard Salesforce page. For an example, if we use some standard Accounts controller, by clicking the Save button in the Visualforce page which results in the similar behavior by clicking Save on a standard Account edit page. Triggers Apex can be started through the use of triggers. A trigger is an Apex code which executes before or after the following types of operations: insert merge upsert upload delete undelete Relationship between the internship and my field of studies A primary objective of internship is to provide students with an opportunity to test abilities and attitudes toward particular material or career possibilities for the future For me classroom learning is important, but it does not provide me with real work experience to prepare me for a career after graduation. Exposure to the workplace environment is needed to bridge the gap between learning in the classroom and application in the work environment. Since I am doing MBA with Management Information Systems as my concentration, it is a great opportunity to get real time work exposure in multi-faceted environment. Salesforce objects and relationships Salesforce Development Life Cycle Stages 7.0 CONCLUSION In review the internship that I have been to work is an excellent and rewarding experience. I was fortunate to meet and work with many people that I am sure will be able to help me with opportunities in the future. The things I have learned from this internship are time management skills and self-motivation as well as work discipline. I never thought I could work eight hours straight everyday for five days in a week. When I realized that I planned my day and work ahead so I dont waste any of my working hours. I made myself to be ready with all the doubts, when it was the correct time to get feedback. This internship motivated me through work in the office continuously for many hours. I also suggested my share of ideas and proposed some proposals that the company is looking forward into using. In conclusion, the internship is an useful experience, I have find out what my strengths and weakness are; I gaining new knowledge and skills and met many new people, I am achieving many of my learning goals, however for some the conditions did not permit to achieve them as I wanted. This Internship is giving me new insights and motivation to pursue a career as a salesforce developer. To prepare myself for my future career I can improve several things. I can work on my communication skills so that I am able to present and express myself more confidently. 8.0 APPENDICES THANK YOU ******************************************************************

Effective Devices :: Linguistics Language Communication Essays

Effective Devices There is a description of the family who migrated from Vietnam to the US, and they are having a language problem inside of family in the essay, â€Å"Language Use in Family and in Society,† from the English textbook, Constructing Others, Constructing Ourselves. (Lee Thomas, Linh Cao 61 -71). The parents cannot speak English although the children are comfortable with speaking English. As a result, the parents and children cannot communicate appropriately in various situations, and the parents have lost their authority on their children. The children do not respect their parents because they cannot be proud of their parents. In fact, the majority of people who migrated to the US forget their mother tongue after coming to the US because it is no longer necessary for them. The authors, Lee Thomas and Linh Cao, inform us to take this issue as a serious thing for the future of the U.S. In this essay, they use very effective strategies to help the audience understand this issue. I will analyze this essay by using the concepts of rhetorical triangle, structure of the argument, and rhetorical appeals. First, I use rhetorical triangle to analyze the essay. First, Lee Thomas and Linh Cao are the authors of this essay. Lee Thomas teaches linguistics courses in the English department at the University of Nevada, Reno, and Linh Cao is also an English teacher at Sparks High School in Nevada. There are professionals in the study of English. Secondly, the audience is English teacher, people who are in this situation, people who are interested in this problem, and the US government. Third, the purpose is to inform to the US government and American people about the issue that parents and children who cannot communicate with their family because of the different languages which they are familiar with individually. The issue has not well known to the majority of people in the U.S. However, the number of people in this situation will increase in the future because of immigration to the US, and it will continue to cause serious problems. Secondly, I will analyze the essay in terms of the structure of the argument. There are five different aspects.

Pornography †Government Censorship Will Never Promote Equality :: Argumentative Persuasive Argument Essays

Pornography – Government Censorship Will Never Promote Equality Catharine Mackinnon seeks to be the Galileo of sexual inequality: the philosopher free of preconceptions who reveals a new structure, incorporating all known facts, radically different from anything previously understood. The structure Galileo overthrew was the Earth-centered universe. The structure Mackinnon must overthrow, in order to make the law do what she thinks it must, is the First Amendment- centered universe (though Mackinnon would probably say it was the pimp-centered universe; pimp is a favorite term of hers). If you have a hammer, everything looks like a nail; Mackinnon is a lawyer, so the law looks like the best way, or the only way, to solve the problem of pornography. If you divorce Mackinnon's conclusions from her prescriptions, you would have a valuable feminist scholar, calling attention to contexts and subtexts in our society previously ignored. But, as an attorney and law professor, Mackinnon must, to accomplish her goals, place herself squarely in confrontation with free speech. This is doubly sad, because the idea she presents us with is so valuable. Mackinnon's central idea is that pornography is the oppression of women; it is not simply talk about or advocacy of oppression. Thus, she argues, contrary to most Constitutional scholars, that pornography is not speech, but action. In Mackinnon's opinion, pornography acts against women twice, when it is made, and when it is viewed. First, women are degraded, raped and (in her belief) even killed in the making of pornographic pictures and films. Then, the pictures and films further participate in the degradation, rape and murder of women by the users of pornography. To cite just one example from Mackinnon's Only Words, Linda Marchiano, then known as Linda Lovelace, was beaten and threatened at gunpoint by her husband during the filming of Deep Throat. The movie then caused men to force women to try acts which Marchiano had only been able to perform under hypnosis. According to Mackinnon, numerous women were hospitalized directly as a result of the film; some were raped by strangers, others were coerced or raped by boyfriends. (Mackinnon and her colleague, Andrea Dworkin, do not really distinguish between rape and psychological coercion; in fact, to Dworkin, all heterosexual sex seems tantamount to rape.) While Mackinnon's world view, thus summarized, may sound extreme, a thought experiment is all that is really necessary to see the validity of her ideas.

The Role Of Intellectuals In The Rise Of Marxism History Essay

Marxism refers to the socio-political and economic universe position which proposes socialism as a political political orientation to transform society into a better entity. The conceivers of Marxism were Karl Marx together with Friedrich Engels who lived in Britain but had originally migrated from Germany. Basically Marxism interprets society materialistically adopting the thought that societal alteration is driven by category battles where different categories compete to acquire better conditions. Karl Marx and Engels argued that capitalist economy has resulted in subjugation of the lower category that form the bulk in society and does non have belongings by the middle class or the rich. This paper discuses how intellectuals helped in the rise of Marxism and concludes that they were the driving force in its rise. Marxism idea has had a profound influence on intellectuals while intellectuals have contributed a batch to this idea. Many academicians in a broad scope of subjects have adopted the historical apprehension of society espoused by Marxism including political scientists, economic expert, philosophers, psychologists, sociologists, historiographers and a host of many other intellectuals. The period that saw the most important application of Marx idea in societies around the universe was the twentieth century where intellectuals of note advanced the Marxist thought to pervade through political, economic and societal domains of life ( Curtis, 1997 ) . Marxist idea developed into a powerful political and societal motion with Marxist authoritiess taking over power in many states in the universe.Intellectuals and the Rise of MarxismAn rational can be referred to as anybody who employs intelligence-which is fundamentally thought and reason-in a critical and analytical mode at the professional o r personal capacity. Intellectuals advancing the Marxist construct have chiefly dealt with theories and learned thoughts based on the original Marxist theory to develop their ain version of societal alteration effort that has had a large consequence on the rise of Marxism ( Bottomore, 1991 ) . Intellectuals have over clip been interested in Marxism although sometimes with really different positions. Notably, intellectuals have influenced Marxism by virtuousness of the facts that they come from categories within society, they aid in construing constructs and suiting them to specific state of affairss and besides, they are potentially leaders by virtuousness of their apprehension of society and its challenges and chances. Largely, intellectuals have been linked with political orientations and those concerned with Marxism have had a profound impact on the political and societal developments of assorted states in the twentieth century. The Russian revolution in 1917 led to the constitution of the individual most powerful state tally based on Marxist political orientation. The Soviet Union was founded in the twelvemonth 1922 with several leaders of note like Vladimir Lenin, Joseph Stalin and Leon Trotsky being important Marxist theoreticians. Theoretical tendencies like Stalinism, Trotskyism and Marxism-Leninism were branchs of Marxism. In add-on to that, the civil war of China resulted in the people & A ; acirc ; ˆâ„ ¢s democracy of China in 1949 with Mao Zedong, the first leader developing the theoretical Maoism. A figure of states including, Cuba, Nepal, North Korea and Venezuela have besides followed in these lines with leaders who adopted Marxist doctrine set uping Marxist leadings. All these leaders brought around socialist reforms in their states. To get down with, possibly the most of import intellectuals who promoted Marxism were the conceivers, Karl Marx and Friedrich Engels. It is worthy observing that Marxism has taken many dimensions in the class of clip with different theoreticians coming up with their ain versions. This wider position of Marxism can be contrasted to classical Marxism which is what the original minds Karl Marx and Friedrich Engels put frontward as their idea ( Curtis, 1997 ) . Karl Marx was a philosopher and political economic expert who besides became a noteworthy socialist revolutionist. His most noteworthy plants were turn toing issues of development and disaffection of the working category in capitalist economy and besides in developing the Theory of Historical Materialism. Marx analyzed history of worlds history based on category battles and produced the Communist Manifesto together with Friedrich Engels, the most of import of their work. His original thoughts proved really influential at the clip and subsequently particularly after the industrial revolution increased the wealth of states which was acquired by a few persons who oppressed the remainder of society. Marx thesis was ; the history of society has ever been the history of category battles. Following this statements, Marx called for societal alteration where he urged the exploited working category to lift up against the opinion category and the wealthy so as to accomplish a just distribution of resources ( Krygier, 1994 ) . As already stated, Friedrich Engels was an confederate of Marx and the carbon monoxide writer of the Communist pronunciamento and the Communist theory. Engels was a political philosopher who alongside Marx was deported from several states in Europe due to his political and societal positions. For case, after the publication of the Communist pronunciamento in 1848, both Marx and Engels had to travel to Cologne after Belgium threw them out. The two wrote several other plants and published politically extremist newspapers advancing the Communist ideals that they held. Notably, although the two came up with a new and independent idea, they were greatly influenced by former minds and philosophers. Karl Marx drew his influences from classical Germany doctrine, early Gallic socialism and besides from classical British economic sciences ( Pejovich, 1990 ) . Gallic socialists saw capitalist economy as advancing a bad societal organisation, that of private belongings rights and hence capitalist economy. They blamed it for working category poorness, income inequality, kid labour, unemployment and many of the societal jobs. These thoughts were held by Marx as true ( Pejovich, 1990 ) . Philosophers from Germany like Hegel, Immanuel Kant and Ludwig Feuerbach besides influenced Marx thought a batch. Hegel for illustration tried to explicate a Social Change Theory stating that human history has been shaped by alterations in the societal construction coming from within the societal system. Marx besides developed his Theory of Historical Materialism based on this basic thought ( Pejovich, 1990 ) . Furthermore, Marx borrowed from the British economic expert David Ricardo the Labor Theory of Value. The theory fundamentally espoused that any trade good & A ; acirc ; ˆâ„ ¢s value can be equated to the figure of hours needed to bring forth it. To Karl Marx excessively, the working category were being exploited when the capitalist took the far greater excess and paid workers meagre rewards.Significant Modern TheoristsAssorted other intellectuals built upon the Marxist theory and came up with discrepancies that drove political and societal alteration in societies across the universe. One of these discrepancies and possibly the most noteworthy in footings of followings and impact is Marxism-Leninism. Besides known as Collectivism or as many like to mention to it, communism, it had its ideological beginnings from Vladimir Lenin and other Russian intellectuals parts to Marx idea. As a immature adult male, Lenin was involved in practising jurisprudence before acquiring into political relations where he did radical propaganda. He was arrested and jailed for some months before being sent to expatriate in Siberia where he published many theoretical plants ( Read, 2005 ) . Lenin subsequently became the leader of a split Social Democratic Labor Party which sought to subvert the Tsarist government. The split was occasioned by the differing ideological positions about the most suited manner of conveying societal alteration to Russia with Lenin staying with the Bolshevik cabal that finally took power ( Read, 2005. Basically, what Lenin and fellow intellectuals did was usage assorted agencies to distribute Marxist political orientations to the in-between category in Russia so as to make possible for a revolution by beat uping the working category and other lower categories against the opinion category. This work is what eventually led to the revolution of 1917 in Russia that introduced Marxist political orientation into the political and societal landscape of Russia widely referred to as communism ( Read, 2005 ) . Lenin introduced a socialist system of administration in Russia that replaced the absolute regulation of the Tsars. As a organic structure of idea, Marxism-Leninism was later closely identified with Joseph Stalin as its figure caput when Lenin died. Over clip nevertheless, there were ideological developments within the same political orientation of Marxism-Leninism that creped up within Russia itself. These schools of idea continued to act upon the pattern of socialism in Russia and its orbiters for a long clip therefore keeping Marxism together. Some of the major goings from the original Marxist-Leninism were the denouncing of the cult of personality that had developed around Stalin by Nikita Khrushchev and the dogma that category struggles go on even under socialism. Marxism political orientations continued playing a large portion of Russia & A ; acirc ; ˆâ„ ¢s personal businesss up to the decennary of 1990s. The long being of the Marxist pattern was enabled by the being of communist party members who continued advancing Marxist political orientations even exporting it to other states apa rt from the USSR during the cold war epoch. Intellectuals back uping Marxism would acquire educated in communist states and travel back place to form revolutions. Chinese pupils were exposed to western socialism largely in Japan which was comparatively developed at the clip. The degree of rational involvement in Marxism amongst the Chinese was reasonably low in early twentieth century but changed when Russia managed the Bolshevik revolution and besides when the May Fourth Movement occurred in China. Harmonizing to Daniels ( 1987 ) , the East particularly China was non attracted to communism by Marxian analysis of history as subjugation of the lower category by the rich and powerful. Communism appealed to intellectuals of the East as a new subject and manner of life that would set their state in a better place to industrialise and derive national power to be able to vie with other states of the West which were good in front in footings of development. It really presented them with a manner of occidentalizing without really copying the West. Bing chiefly an agricultural economic system, Chinese Marxist intellectuals used the peasantry to advance their aspirations for a revolution by mentioning to it as the radical category. The sheer Numberss of the peasantry made it possible for the Chinese Marxists to prevail. The communist motion in China was really much divorced from workers in the old ages prior to the Communists presuming power. It was fundamentally used as an look of intellectuals who were extremist minded. Mao Tse-tung was the one intellectual who pushed for a engagement of the provincials to assist convey about a revolution ( Daniels, 1987 ) . The communist motion in China was therefore headed by intellectuals who followed the Marxian political orientation that the working and lower category must unify and lift up against the opinion category so as to convey societal alteration. Intellectuals saw this as an chance to utilize the people non merely to convey the much needed societal alteration but besides come up with political alterations with them at the helm. In China, there existed many approaching intellectuals who holding been schooled in western instruction started to dispute traditional Chinese doctrine and faulting it for the jobs in China at the clip. Knight ( 2005 ) says the most noteworthy intellectuals who promoted Marxist political orientations included Mao Zedong, Qu Quibai, Ai Siqi and Li Dazhao. The four and others were basically revolutionists who used doctrine to acquire a better apprehension of the universe and a manner of rushing up alteration in the state. Marxism and the political orientations expressed in it were new to Chinas cultural agreements because the positions developed outside China. However, Marxism as already noted, was found to be appealing by the Chinese intellectuals because of the possible benefits of altering the Chinese society and delivery development in the state. Mao Zedong was peculiarly influential in advancing communism in China and initiated many efforts at cultural alterations in the state which involved a batch of grassroots mobilisations that built on Marxist ideological entreaty. The cult of Mao created by Mao Zedong and his close associates was besides of import in fostering the dogmas of Marxism and therefore steadfastly set uping communist leading.An Analysis of Marxism entreaty to IntellectualsNovack ( 1935 ) argues that the clerisy of any society do non do up a category and make non by any agencies stand above the categories. Intellectuals are a group which is made up of members who are consciously or unconsciously pressed into functioning all categories. This group is really heterogenous due to the fact that it is drawn from different categories. They have different commitments, societal beginnings and aspirations. Thus the map of intellectuals is to joint issues and political orientations for the benefit of all members and cate gories of society. Although the intellectuals have ever held a better place in society ( most come from the in-between category ) than the lower category which is down trodden, Marxism held a great entreaty to both of these groups. Again, holding no other theory to explicate the history of human dealingss, Marxism seemed logical plenty and still does to intellects ( Perry et al, 2009 ) . As Karl Marx himself observed, the rational are in a better place to rule others in the societal agreement by virtuousness of their cognition and ability ( Rockmore, 2002 ) . The intellectuals hence saw an chance in socialism where they could take the bulk of people to arise against the opinion category and therefore set up better conditions for all. This entreaty was so great and is what led intellectuals to mobilise the working categories and the hapless to lift against the swayers. By distributing these thoughts, the intellectuals played the greatest portion in the rise of Marxism and its outcrops in many states around the universe. Intelligibly, Marxism is an ideological motion with really extremist propositions but one that had non been tried before. To intellectuals, the statement in this political orientation was logical and straightforward and given the many jobs afflicting many societies in the universe, intellectuals saw Marxism as the greatest hope for humanity.DecisionMarxism has held a great ideological entreaty to non lone intellectuals but besides the disadvantaged in society. Although its application proved a failure in the twentieth century with the diminution of communist governments, the political orientation continues to hold great entreaty to intellectuals across the universe. The work of intellectuals being the critical and originative analysis of ideological concepts, it has been instrumental in act uponing societies to follow Marxism and convey societal alteration. Intellectuals have promoted Marxism by coming up with thoughts about socialist society and suiting them to the peculiar contexts from which they come from. Besides, intellectuals have been instrumental in existent mobilisation of the hapless and working category to convey about revolutions across the universe. Notably, it is intellectuals who rose to the helm of political leading of the Communist regimes that came up during the twentieth century. In this manner, they were able to advance the rise of Marxism around the universe.

Becoming a Citizen of Trinidad and Tobago

CONTENTS Definition of Personality†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦2 How a person becomes a citizen in Trinidad and Tobago†¦.. 3 Roles of a Citizen †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 7 Qualities of an outstanding citizen †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦8 Pictures of Document †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦9 DEFINITION OF PERSONALITY: According to the American Psychological Association, personality refers to the individual differences in characteristic patterns of thinking, feeling and behaving. These patterns can be observed amongst all living organisms within the universe. Personality is the essential character of a person and is that aspect of every human being that impresses others. HOW A PERSON BECOMES A CITIZEN OF TRINIDAD AND TOBAGO: This is the complete legal process of becoming a Trinidad and Tobago citizen- 1. A person must apply to be a citizen at through the ministry of national security. 2. You must fulfill these criteria: * The spouse of a resident or citizen of Trinidad and Tobago. * The parent or grandparent of a resident or citizen of Trinidad and Tobago who resides in the country and is willing and able to provide care and maintenance for you. * Working in Trinidad and Tobago under a Work Permit for five or more continuous years at the time of application. However, a former resident or citizen of Trinidad and Tobago who wishes to obtain residency again would have to: * Obtain a Police Certificate of Character from all countries of residence within the last five years and from Trinidad and Tobago. Please follow the link below for information on obtaining a Police Certificate of Character from Trinidad and Tobago. Certificates must not be dated more than six months before the date of application. * Have legally entered the country if you are currently living in Trinidad and Tobago. Not be in a prohibited class as outlined in Section 8(1) of Immigration Act. The Immigration Act can be viewed in its entirety on the Ministry of National Security's Immigration Division website. 3. You must obtain and complete two copies of a â€Å"P&I 6 Form† from one of the offices below, or from any Trinidad and Tobago overseas mission. These are available at: 1. Citizenship and Immigration Section Temple Court 31-33 Abercromby Street, Ground Floor Port of Spain Trinidad, West Indies Phone: (868) 623-2441-5 Fax: (868) 625-9405 E-Mail:  [email  protected] ov. tt 2. Immigration Office Port Authority Building Milford Road Scarborough Tobago, West Indies Tel: (868) 639-2681 Fax: (868) 639-1868 3. Both copies of the application form should be completed in accordance with the included instructions and returned in person, together with all required documentation. REQUIRED DOCUMENTATION: * Four identical passport-sized photos taken within the last six months. * Birth Certificate and supporting Affidavit, if necessary (original and one copy). * Marriage Certificate, if applicable (original and one copy). Police Certificate of Character from previous counties of residence within the last five years and from Trinidad and Tobago, dated not more than six months from the date of application. * Work Permits issued in the name of the applicant for five years (original and one copy). * Job Letter or, if self-employed, evidence of registrat ion of Company and letter indicating nature of employment and income. * Financial statements reflecting any investment accounts, bank accounts or credit union accounts dated not more than two weeks before date of application. Tax Clearance Certificate â€Å"B† or â€Å"C†, which can be obtained at the Inland Revenue Department, Trinidad House, St. Vincent Street, Port of Spain. * Photocopies of each utilised page of a valid foreign Passport. The required documentation may vary according to the reason for applying for residency in Trinidad and Tobago. 4. The following fees are payable upon approval of an application for Resident Status: * Nationals of Caribbean Community (CARICOM) countries pay TT$400. 00. Nationals of non-CARICOM countries pay TT$1000. 00. Payment must be made in cash or by certified cheque at: Cashier's Unit Ground Floor, Ministry of National Security 31-33 Abercromby Street, Port of Spain Trinidad, West Indies The Cashier's Unit is open Monday throug h Friday from 8:00 am to 2:30 pm, except public holidays. If application was made at an Overseas Mission you are required to enter Trinidad and Tobago once your Resident Status is approved to pay your fees and to collect your Certificate of Resident Status. AFTER APPLICATION: All applications are placed in a queue in the order in which they are received. Staff from the Citizenship and Immigration Section will review each application and, if necessary, request omitted information. Once an application is deemed to be complete, the Ministry will send written notification to the applicant of the date and time he or she has been scheduled for an interview. During the interview, an Immigration Officer will determine if the applicant qualifies for Resident Status. After the interview, the Ministry will send the applicant written notification of the final decision regarding his or her application for Resident Status. The period of time from when you apply to final decision may vary from one to four years. ROLES OF A CITIZEN: As a citizen of Trinidad and Tobago many roles must be played. There are rights and responsibilities that are required in order to fulfill the position of a legal Trinidad and Tobago resident. The rights, roles and responsibilities of a citizen are available in the Trinidad and Tobago constitution. These rights are: the right of the individual to life, liberty, security of the person and enjoyment of property And the right not to be deprived thereof except by due process of law; * the right of the individual to equality before the law and the protection of the law; * the right of the individual to respect for his private and family life; * the right of the individual to equality of treatment from any public authority in the exercise of any functions; * the right to join political parties and to express political views; * the right of a parent or guardian to provide a school of his own choice for the education of his child or ward; * freedom of movement; * freedom of conscience and religious belief and observance; * freedom of thought and expression; * freedom of association and assembly; and * Freedom of the press. QUALITIES OF AN OUTSTANDING CITIZEN: An outstanding citizen must display characteristics that have a positive and significant impact on the country. Becoming a good citizen in take obeying the law, voting, paying attention to government and politics, donating money to help others, volunteering to help others and helping with problems and issues within society. Excelling at these and other duties amongst society creates the perfect example of what an outstanding model citizen can be. Being an outstanding citizen comes with great results. Awards and privileges are given with the act of outstanding citizenry and a rich and prosperous lifestyle awaits the achiever.